That's A Lot of Esomeprazole

And it didn't work (for sepsis).

I never knew this was a thing – but, now, we do.

And, no doubt, it is unlikely we will ever try this again.

PPI-SEPSIS was a randomized, double-blind, placebo-controlled trial conducted in Italy, Russia, and Kazakhstan where they received “mega-dose” esomeprazole as an adjunctive treatment for sepsis, a total of 1024mg over the first 72 hours after randomization.

It’s reasonable to say there’s no profound signal either way:

But it was a very interest concept to hear about!